Nanoparticles + Stem Cells = Wolverines healing ability, almost

Posted: October 13, 2009 in Medicine
Tags: , , , , ,

The article:

A new study may have hit upon another way to improve stem cells‘ ability to help repair damaged tissue. While stem cells can rapidly grow into any kind of new tissue, they aren’t always able to encourage new blood vessels to grow so that the tissue stays alive. But in a new study, published in the Proceedings of the National Academy of Sciences, scientists describe a way around the problem. The researchers used nanoparticles to ferry a key gene into the stem cells, which caused the cells to recruit new blood vessels, thus fueling tissue growth.

The nanoparticles carried a gene (VEGF) that is known to stimulate new blood vessel growth. When the modified cells were injected into mice whose hind limbs had been injured, the tissue that regrew to repair the damage had three times the blood vessel density of similar tissue in mice given unmodified cells. Four weeks later, only 20 per cent of the mice given modified cells had lost limbs, compared with 60 per cent in mice that received unmodified cells.

The researchers are optimistic about the nanoparticle approach, however they state in the study that the effect may be transient. They note that there was a significant increase in VEGF levels in mouse muscle two days following cell grafting, but VEGF levels produced by the cells dropped sharply after four days. They say that using a virus to transmit the gene may be a better approach to stimulate new blood vessels over a longer period of time. However, the viral approach is not without risks–viruses can integrate into the genome of cells and linger permanently, potentially causing cancer or immune reactions.

Wow as long as we can overcome the cancer problem this could be very useful. I love being alive at this moment in time because it feels like every day that goes by were doing something that just 20 years ago was considered to be science fiction.

Just think about what the next 20 years will be like.

Original site.

WOG out.

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